Omniheroes – Hero Rune & Substat Optimization Guide

This list is not ordered as we have a Rune Priority List for that.

Guide to Hero Rune & Substat Optimization

By Azu

Atropos

• x4 DPS
• 2 CRIT Res + 2 Ultimate substats (recommended)
• Ultimate boosts both damage and the effect of abilities. For Atropos, it could enhance the 40% ATK buff to allies, potentially increasing the percentage further.

Nawi

• x4 DPS – Substat: CRIT Res / Basic Attack

Mavis

• 4 ATK with Ultimate substats
• If investing further:
• 4 Dodge with Unique/Supreme and Ultimate substats

Catherine

• x4 DPS – Substat: Cure Rate (12*); if lower, ATK

Astrid

• x4 DPS for PvE, x4 Dodge for PvP
• Split between Cure Rate and Ultimate substats
• Unique helps with extra ATK but can be acquired later

Halysa

• x4 Reflect (PvE)
• x4 Dodge (PvP) – Substat: ATK / Ultimate / Unique

Salleine

• x4 DPS – Substat: ATK
• if investing further:
• x4 Dodge Supreme.

Janna

• x4 Dodge – Substat: ATK / Ultimate; Needs Unique

Dahlia

• x4 DPS

Ophelia

• x4 Dodge

Seraphina

• x4 Dodge

Lamia

• Use Reflect if her runes are Supreme.
• Without her Legendary (Leg) version, it’s better to stick with ATK set for higher overall damage.
• Substat: Ultimate

Dorabella

• x4 DPS – Substat: Basic Attack

Nyx

• x4 DPS – Substat: Ultimate / CRIT Res (if 12*); preferably Unique

Karnak

• DPS set with ATK or Ultimate substats is fine.
• Unique isn’t necessary.

Eudora

• DPS set – 4 Ultimate substats
• Either normal or Supreme runes; Unique isn’t very beneficial.

Doris

• 4 Reflect with Supreme (if possible)
• For Leg runes (if not going for Supreme), use Dodge or DPS since Doris primarily provides double Reflect for the team.

Audrey

• Dodge or DPS set – Substat: CRIT Res / Ultimate

Narissa

• DPS or Dodge set – Substat: Ultimate
• Unique / Supreme preferred.